Molecular mimicry may contribute to pathogenesis of ulcerative colitis

Downregulation of miR-214-3p May Contribute to Pathogenesis of Ulcerative Colitis via Targeting STAT6

MicroRNAs (miRs) are small noncoding RNA molecules and recently have demonstrated that altered expression and functions are their tight association with ulcerative colitis (UC). Previous microarray study reported that miR-214 was downregulated in the sigmoid colon of patients with active UC, but the roles of miR-214 in the pathogenesis of UC remain to be elucidated. In this study, significant l...

Decreased serum level of lipoxin A4 (LXA4) may contribute to the pathogenesis of allergic rhinitis

Background: Rhinitis is a prevalent chronic inflammatory disease of the nasal mucosa. Arachidonic acid-derived lipoxin A4 (LXA4) has long been recognized to exert crucial anti-inflammatory and pro-resolving effects on inflammatory responses through a specific receptor named formyl peptide receptor-2 (FPR2). This study aimed to determine the serum level of LXA4 as well as the relative mRNA expre...

Up-Regulation of microRNA-126 May Contribute to Pathogenesis of Ulcerative Colitis via Regulating NF-kappaB Inhibitor IκBα

BACKGROUND MicroRNAs (miRNAs) are important post-transcriptional regulators. Altered expression of miRNAs has recently demonstrated association with human ulcerative colitis (UC). In this study, we attempted to elucidate the roles of miR-126 in the pathogenesis of UC. METHODS Expression of miR-126, miR-21, miR-375 and the potential targets NF-κB inhibitor alpha (IκBα, IKBA or NFKBIA), Polo-li...

Pathogenesis of strictures in ulcerative colitis: a field to explore.

New Onset Ulcerative Colitis: Case Analysis and Correlations to Pathogenesis

New onset ulcerative colitis appearing with or soon after an associated comorbidity represents a unique opportunity to analyze and identify the events that may have triggered the colonic inflammation. The characteristic colonic mucosal inflammatory manifestations observed in ulcerative colitis lends itself to a common pathway analysis within the pathophysiology of associated comorbid triggering...